Catalog No.: PC-20376Not For Human Use, Lab Use Only.
ND-646 (ND646) is a potent, selective and allosteric inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of 3.5 and 4.2 nM for hACC1 and hACC2, respectively.
ND-646 (ND646) is a potent, selective and allosteric inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of 3.5 and 4.2 nM for hACC1 and hACC2, respectively.
ND-646 interacts within the dimerization site of the BC domain of ACC, specifically binds to Arg172 in human ACC1 (hACC1R172) and Arg277 in human ACC2 (hACC2R277).
ND-646 treatment led to a complete loss of P-ACC detection in A549 cells without affecting total ACC protein levels.
ND-646 inhibits fatty acid synthesis (FASyn) in vitro, depletes cellular levels of fatty acids and induces apoptosis in NSCLC cells.
ND-646 (25 mg/kg QD) inhibits tumor growth in A549 NSCLC xenograft models.
ND-646 inhibits FASyn in lung tumors of KrasG12D p53−/− and KrasG12D Lkb1−/− mouse models of NSCLC and lowers plasma free fatty acids.
ND-646 suppresses KrasG12D p53−/− and KrasG12D Lkb1−/− autochthonous NSCLC tumor growth.
