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Chemical Structure : ND-646
CAS No.: 1434639-57-2
Catalog No.: PC-20376Not For Human Use, Lab Use Only.
ND-646 (ND646) is a potent, selective and allosteric inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of 3.5 and 4.2 nM for hACC1 and hACC2, respectively.
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| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
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| 50 mg | Get quote | ||
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ND-646 (ND646) is a potent, selective and allosteric inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of 3.5 and 4.2 nM for hACC1 and hACC2, respectively.
ND-646 interacts within the dimerization site of the BC domain of ACC, specifically binds to Arg172 in human ACC1 (hACC1R172) and Arg277 in human ACC2 (hACC2R277).
ND-646 treatment led to a complete loss of P-ACC detection in A549 cells without affecting total ACC protein levels.
ND-646 inhibits fatty acid synthesis (FASyn) in vitro, depletes cellular levels of fatty acids and induces apoptosis in NSCLC cells.
ND-646 (25 mg/kg QD) inhibits tumor growth in A549 NSCLC xenograft models.
ND-646 inhibits FASyn in lung tumors of KrasG12D p53−/− and KrasG12D Lkb1−/− mouse models of NSCLC and lowers plasma free fatty acids.
ND-646 suppresses KrasG12D p53−/− and KrasG12D Lkb1−/− autochthonous NSCLC tumor growth.
| M.Wt | 568.65 | |
| Formula | C28H32N4O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide |
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1. Svensson RU, et al. Nat Med. 2016 Oct;22(10):1108-1119.
2. Li EQ, et al. Eur J Pharm Sci. 2019 Sep 1;137:105010.
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