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Chemical Structure : ND-654
Catalog No.: PC-36170Not For Human Use, Lab Use Only.
ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.
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ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.
ND-654 inhibits HepG2 cell fatty acid synthesis with an EC50 of 14 nM, and reduces both rat hepatic malonyl-CoA and rat hepatic fatty acid synthesis with ED50 values of 0.34 mg/kg and 0.30 mg/kg at Cmax, respectively.
ND-654 mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC.
ND-654 selectively targets the liver and inhibits HCC proliferation, improves survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib.
| M.Wt | 583.656 | |
| Formula | C29H33N3O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lally JSV, et al. Cell Metab. 2019 Jan 8;29(1):174-182.e5.
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