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NDI-091143

Chemical Structure : NDI-091143

CAS No.: 2375840-87-0

NDI-091143 (NDI 091143, NDI091143)

Catalog No.: PC-36165Not For Human Use, Lab Use Only.

NDI-091143 (NDI091143) is a potent, small-molecule inhibitor of human ATP-citrate lyase (ACLY) with Ki of 7.0 nM and IC50 of 2.1 nM in the ADP-Glo assays.

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Biological Activity

NDI-091143 (NDI091143) is a potent, small-molecule inhibitor of human ATP-citrate lyase (ACLY, ACL) with Ki of 7.0 nM and IC50 of 2.1 nM in the ADP-Glo assays.
NDI-091143 is located in an allosteric, mostly hydrophobic cavity next to the citrate-binding site, and requires extensive conformational changes in the enzyme that indirectly disrupt citrate binding.

Physicochemical Properties

M.Wt 453.841
Formula C20H14ClF2NO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate

References

1. Wei J, et al. Nature. 2019 Apr 3. doi: 10.1038/s41586-019-1094-6.

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