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Chemical Structure : NDI-091143
CAS No.: 2375840-87-0
Catalog No.: PC-36165Not For Human Use, Lab Use Only.
NDI-091143 (NDI091143) is a potent, small-molecule inhibitor of human ATP-citrate lyase (ACLY) with Ki of 7.0 nM and IC50 of 2.1 nM in the ADP-Glo assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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NDI-091143 (NDI091143) is a potent, small-molecule inhibitor of human ATP-citrate lyase (ACLY, ACL) with Ki of 7.0 nM and IC50 of 2.1 nM in the ADP-Glo assays.
NDI-091143 is located in an allosteric, mostly hydrophobic cavity next to the citrate-binding site, and requires extensive conformational changes in the enzyme that indirectly disrupt citrate binding.
| M.Wt | 453.841 | |
| Formula | C20H14ClF2NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate |
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1. Wei J, et al. Nature. 2019 Apr 3. doi: 10.1038/s41586-019-1094-6.
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