NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.
NDMC101 markedly inhibits RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).
NDMC101 significantly reduces the bone-resorbing activity of mature osteoclasts.
NDMC101 reduces arthritic index and mitigated bone erosion in CIA mice.
Physicochemical Properties
M.Wt
265.7
Formula
C13H9ClFNO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide
References
1. Cheng CP, et al. J Clin Immunol. 2012 Aug;32(4):762-77.
2. Liou JT, et al. Eur J Pharmacol. 2014 Mar 5;726:124-32.
3. Lee CC, et al. Eur J Med Chem. 2015 Jun 15;98:115-26.
