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NE-100

Chemical Structure : NE-100

CAS No.: 149860-29-7

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NE-100 (NE 100, NE100)

Catalog No.: PC-60288Not For Human Use, Lab Use Only.

NE-100 is a potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM.

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5 mg $148 In stock
10 mg $228 In stock
25 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NE-100 is a potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM.
NE-100 dispalys 205-fold selectivity over sigma-2, 1,000-fold selectivity over D1, D2, PCP, α1, 5-HT1A and 5-HT2 receptors.
NE-100 shows antipsychotic activity in vivo.

Physicochemical Properties

M.Wt 355.51
Formula C23H33NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine

References

1. Nakazato A, et al. J Med Chem. 1999 Mar 25;42(6):1076-87.

2. Berardi F, et al. Bioorg Med Chem. 2001 May;9(5):1325-35.

3. Ogawa S, et al. Eur J Pharmacol. 1994 Sep 22;263(1-2):9-15.

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