Chemical Structure : NE-100 hydrochloride
CAS No.: 149409-57-4
Catalog No.: PC-60289Not For Human Use, Lab Use Only.
NE-100 hydrochloride is a potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM.
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NE-100 hydrochloride is a potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM.
NE-100 dispalys 205-fold selectivity over sigma-2, 1,000-fold selectivity over D1, D2, PCP, α1, 5-HT1A and 5-HT2 receptors.
NE-100 shows antipsychotic activity in vivo.
| M.Wt | 391.97 | |
| Formula | C23H33NO2.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride |
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1. Nakazato A, et al. J Med Chem. 1999 Mar 25;42(6):1076-87.
2. Berardi F, et al. Bioorg Med Chem. 2001 May;9(5):1325-35.
3. Ogawa S, et al. Eur J Pharmacol. 1994 Sep 22;263(1-2):9-15.

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