You are here:Home-Chemical Inhibitors & Agonists-GPCR-Proton-sensing GPCRs-NE 52-QQ57
NE 52-QQ57

Chemical Structure : NE 52-QQ57

CAS No.: 1401728-56-0

NE 52-QQ57 (NE52-QQ57, GPR4 antagonist 13)

Catalog No.: PC-20835Not For Human Use, Lab Use Only.

NE 52-QQ57 (GPR4 antagonist 13) is a potent, elective, and efficacious GPR4 antagonist with IC50 of 70 nM (hGPR4).

Packing Price Stock Quantity
10 mg $188 In stock
25 mg $298 In stock
50 mg $488 In stock
100 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NE 52-QQ57 (GPR4 antagonist 13) is a potent, elective, and efficacious GPR4 antagonist with IC50 of 70 nM (hGPR4).
GPR4 antagonist 13 displays no significant inhibition against a panel of enzymes, receptors, and ion channels.
GPR4 antagonist 13 is also selective over the related proton sensing receptors OGR1 and TDAG8.
GPR4 antagonist 13 weakly inhibits rat GPR4 with IC50 of 1.84 uM.
GPR4 antagonist 13 shows significant efficacy in the rat antigen induced arthritis as well as in the hyperalgesia and angiogenesis model at a well-tolerated dose of 30 mg/kg.

Physicochemical Properties

M.Wt 416.53
Formula C24H28N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

References

1. Juraj Velcicky, et al. J Med Chem. 2017 May 11;60(9):3672-3683.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: