NEDD8 inhibitor M22 |CAS:864420-54-2 Probechem Biochemicals

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Chemical Structure : NEDD8 inhibitor M22

CAS No.: 864420-54-2

NEDD8 inhibitor M22

Catalog No.: PC-62879Not For Human Use, Lab Use Only.

NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.

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5 mg	$198	In stock
10 mg	$328	In stock
25 mg	$548	In stock
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Biological Activity

NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.
M22 inhibit A549 cell proliferation completely at 30 uM (GI50=5.5 uM and GI90=19.3 uM).
M22 produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in zebrafish model。
M22 exhibts different binding mode compared with MLN4924.

Physicochemical Properties

M.Wt	363.326
Formula	C20H24Cl2N2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-N-(2,4-dichlorophenethyl)piperidin-4-amine

References

1. Lu P, et al. ACS Chem Biol. 2016 Jul 15;11(7):1901-7.

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NEDD8 inhibitor M22

Biological Activity

Physicochemical Properties

References

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