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Chemical Structure : NFEPP
Catalog No.: PC-35539Not For Human Use, Lab Use Only.
NFEPP is a novel potent, selective pH-dependent μ-opioid receptor (MOR) agonist with a low pKa, shows significantly lower affinity compared with fentanyl at pH 7.4.
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NFEPP is a novel potent, selective pH-dependent μ-opioid receptor (MOR) agonist with a low pKa, shows significantly lower affinity compared with fentanyl at pH 7.4.
NFEPP has been shown to produce injury-restricted analgesia in models of inflammatory and postoperative pain, without exhibiting typical opioid side effects.
NFEPP dose-dependently diminished neuropathy-induced mechanical and heat hypersensitivity, and acetic acid-induced abdominal constrictions in vivo.
| M.Wt | 354.469 | |
| Formula | C22H27FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rodriguez-Gaztelumendi A, et al. Pain. 2018 Jul 2. doi: 10.1097/j.pain.0000000000001328.
2. Del Vecchio G, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1638-1640.
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