Catalog No.: PC-61460Not For Human Use, Lab Use Only.
NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
NFPS ((Rac)-ALX 5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
NFPS inhibits glycine transport by the GlyT1a, b and c subtypes of glycine transporters, but has no effect on the GLYT2a subtype of transporter.
NFPS reverses PCP-induced changes in EEG power spectra in conscious rats (1-10 mg/kg i.p.), significantly enhances long-term potentiation in the hippocampal dentate gyrus in vivo.
