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Chemical Structure : NFPS
Catalog No.: PC-61460Not For Human Use, Lab Use Only.
NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
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NFPS ((Rac)-ALX 5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
NFPS inhibits glycine transport by the GlyT1a, b and c subtypes of glycine transporters, but has no effect on the GLYT2a subtype of transporter.
NFPS reverses PCP-induced changes in EEG power spectra in conscious rats (1-10 mg/kg i.p.), significantly enhances long-term potentiation in the hippocampal dentate gyrus in vivo.
| M.Wt | 393.45 | |
| Formula | C24H24FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aubrey KR, et al. Br J Pharmacol. 2001 Dec;134(7):1429-36.
2. Harsing LG Jr, et al. Pharmacol Biochem Behav. 2003 Mar;74(4):811-25.
3. Bergeron R, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15730-4.
4. Kinney GG, et al. J Neurosci. 2003 Aug 20;23(20):7586-91.
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