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NFPS

Chemical Structure : NFPS

CAS No.: 405225-21-0

NFPS ((Rac)-ALX 5407, ALX5407, (±)-NFPS)

Catalog No.: PC-61460Not For Human Use, Lab Use Only.

NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NFPS ((Rac)-ALX 5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
NFPS inhibits glycine transport by the GlyT1a, b and c subtypes of glycine transporters, but has no effect on the GLYT2a subtype of transporter.
NFPS reverses PCP-induced changes in EEG power spectra in conscious rats (1-10 mg/kg i.p.), significantly enhances long-term potentiation in the hippocampal dentate gyrus in vivo.

Physicochemical Properties

M.Wt 393.45
Formula C24H24FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine

References

1. Aubrey KR, et al. Br J Pharmacol. 2001 Dec;134(7):1429-36.

2. Harsing LG Jr, et al. Pharmacol Biochem Behav. 2003 Mar;74(4):811-25.

3. Bergeron R, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15730-4.

4. Kinney GG, et al. J Neurosci. 2003 Aug 20;23(20):7586-91.

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