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NH125

Chemical Structure : NH125

CAS No.: 278603-08-0

NH125 (NH 125, NH-125)

Catalog No.: PC-70179Not For Human Use, Lab Use Only.

NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells.

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10 mg $128 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells.
NH125 shows relative selectivity over other protein kinases: PKC (IC50=7.5 uM), PKA (IC(50=80 uM), and CaMKII (IC50>100 uM).
NH125 shows efficacious anti-proliferation activityt against different cancer cells.

Physicochemical Properties

M.Wt 524.56
Formula C27H45IN2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Imidazolium, 1-hexadecyl-2-methyl-3-(phenylmethyl)-, iodide (9CI)

References

1. Yamamoto K, et al. Biosci Biotechnol Biochem. 2000 Apr;64(4):919-23.

2. Arora S, et al. Cancer Res. 2003 Oct 15;63(20):6894-9.

3. Chen Z, et al. J Biol Chem. 2011 Dec 23;286(51):43951-8.

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