Chemical Structure : NH300094
CAS No.:
2647419-63-2
NH300094
(NH 300094)
Catalog No.: PC-21760Not For Human Use, Lab Use Only.
NH300094 is a potent antagonist of 5-HT receptors and dopamine receptors with IC50 of 0.47 nM, 1.04 nM, 11.71 nM and 31.55 nM for 5-HT2A, D2L, D2S and D3 receptors, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NH300094 is a potent antagonist of 5-HT receptors and dopamine receptors with IC50 of 0.47 nM, 1.04 nM, 11.71 nM and 31.55 nM for 5-HT2A, D2L, D2S and D3 receptors, respectively.
NH300094 is a triple antagonist of 5-HT2A receptor, dopamine D2 receptor and dopamine D3 receptor.
NH300094 shows high inverse agonist activity of 5-HT1BR (EC50 = 28.36 ± 12.52 nM) and antagonistic activities of 5-HT1AR (IC50 = 85.59 ± 61.53 nM) and D3R (IC50 = 31.55 ± 23.08 nM).
NH300094 (0.01, 0.03, 0.1 and 0.3 mg/kg, oral) resulted in a dose-dependent inhibition of MK-801-induced hyperactivity in male ICR mice with an ED50 of approximately 0.07 mg/kg and Minimum effective dose (MED) of 0.03 mg/kg.
NH300094 shows powerful efficacy in positive, negative, and cognitive impairment animal models.
Physicochemical Properties
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M.Wt
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449.53
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Formula
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C26H28FN3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-(3-(4-(6-fluorobenzo [d]isoxazol-3-yl) piperidin-1-yl) propoxy)-1,2,5,6-tetrahydro-4H-pyrrolo [3,2,1-ij] quinolin-4-one
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References
1. Zijin Feng, et al. Front Pharmacol. 2024 Jan 24:15:1298061.
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