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Chemical Structure : NIDDK/CEB-52
Catalog No.: PC-20500Not For Human Use, Lab Use Only.
NIDDK/CEB-52 (Compound 52) is a potent and selective antagonist for TSH receptor (TSHR), inhibits TSH-mediated cAMP response of TSHR with IC50 of 4.2 uM.
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NIDDK/CEB-52 (Compound 52) is a potent and selective antagonist for TSH receptor (TSHR), inhibits TSH-mediated cAMP response of TSHR with IC50 of 4.2 uM.
NIDDK/CEB-52 is selective toward TSHR when compared with the closely related LHCGR and FSHR.
NIDDK/CEB-52 (10 and 30 uM) inhibits TSH stimulation of TPO mRNA expression in human thyrocytes.
NIDDK/CEB-52 (30 uM) inhibits TSHR activation by thyroid-stimulating antibodies (TsAbs) from patients with Graves' disease.
| M.Wt | 442.60 | |
| Formula | C22H26N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Susanne Neumann, et al. Endocrinology. 2008 Dec;149(12):5945-50.
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