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NIK SMI1

Chemical Structure : NIK SMI1

CAS No.: 1660114-31-7

NIK SMI1

Catalog No.: PC-62514Not For Human Use, Lab Use Only.

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.

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Biological Activity

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.
NIK SMI1 only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM.
NIK SMI1 potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling.
NIK SMI1 inhibits BAFF and CD40 signaling, suppresses immune responses in vivo.
NIK SMI1 suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.

Physicochemical Properties

M.Wt 365.389
Formula C20H19N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-6-(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide

References

1. Brightbill HD, et al. Nat Commun. 2018 Jan 12;9(1):179.

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