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Chemical Structure : NIP-142
Catalog No.: PC-20298Not For Human Use, Lab Use Only.
NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM.
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NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM.
NIP-142 inhibits the hKv1.5 current in a concentration-dependent and voltage-independent manner.
NIP-142 has inhibitory effects on the hKv 1.5 current through interaction with both open and closed states of the channel.
NIP-142 (10 and 100 microM) concentration-dependently prolonged the refractory period and action potential duration in the atrium but not in the ventricle.
NIP-142 completely reversed the carbachol-induced shortening of atrial action potential duration.
| M.Wt | 441.48 | |
| Formula | C23H27N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matsuda T, et al. Life Sci. 2001 Mar 16;68(17):2017-24.
2. Matsuda T, et al. J Pharmacol Sci. 2005 May;98(1):33-40.
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