Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-NJK14047
NJK14047

Chemical Structure : NJK14047

CAS No.: 1800576-41-3

NJK14047 (NJK 14047, NJK-14047)

Catalog No.: PC-62614Not For Human Use, Lab Use Only.

NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.
    NJK14047 inhibits RSV- and influenza A-mediated p38 MAPK activation in epithelial cells, decreases viral replication and viral mRNA synthesis.
    NJK14047 also displays significant anti-HBV activity, efficiently suppresses the secretion of HBV antigens and HBV particles from HBV genome-transfected cells.

    Physicochemical Properties

    M.Wt 445.515
    Formula C27H27NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-cyclopropyl-4'-(4-(2,3-dihydroxypropoxy)benzoyl)-6-methyl-[1,1'-biphenyl]-3-carboxamide

    References

    1. Kim SY, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00214-17.

    2. Choi MS, et al. Biochem Biophys Res Commun. 2016 Aug 26;477(3):311-6.

    3. Heo J, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3694-8.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: