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Chemical Structure : NJK14047
Catalog No.: PC-62614Not For Human Use, Lab Use Only.
NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.
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NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.
NJK14047 inhibits RSV- and influenza A-mediated p38 MAPK activation in epithelial cells, decreases viral replication and viral mRNA synthesis.
NJK14047 also displays significant anti-HBV activity, efficiently suppresses the secretion of HBV antigens and HBV particles from HBV genome-transfected cells.
| M.Wt | 445.515 | |
| Formula | C27H27NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim SY, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00214-17.
2. Choi MS, et al. Biochem Biophys Res Commun. 2016 Aug 26;477(3):311-6.
3. Heo J, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3694-8.
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