Catalog No.: PC-20892Not For Human Use, Lab Use Only.
NJNU-0069-003 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN with Kd of 7.98 uM.
NJNU-0069-003 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN with Kd of 7.98 uM.
NJNU-0069-003 increases the expression of MHC-II genes, dose-dependently upregulates the surface MHC-II protein levels in 4T1 mouse cancer cells and human cancer cells including MCF-7 and Hs578T.
NJNU-0069-003 cannot upregulate the expression of IFN-γ responsive genes and was unable to activate the JAK/STAT signaling pathway.
NJNU-0069-003 (100 mg/kg for four times every other day) can effectively inhibit the growth on Balb/c mice bearing 4T1 tumors, fires up the tumor microenvironment by promoting immune detection.
