Chemical Structure : NJNU-0069
CAS No.:
NJNU-0069
Catalog No.: PC-20891Not For Human Use, Lab Use Only.
NJNU-0069 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN (Kd=32.1 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NJNU-0069 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN (Kd=32.1 uM).
NJNU-0069 potently elevated the expression of MHC II genes and upregulated the surface MHC-II protein levels in a dose-dependent manner in cancer cells, including 4T1, MCF-7, and Hs578T.
NJNU-0069 is an analog of pristane, exhibits about 26-fold higher binding affinity to MAT than pristane did (NJNU-0069 Kd: 32.1 μM vs. pristane Kd: 840.6 μM).
NJNU-0069 (100 mg/kg for four times every other day) can effectively inhibit the growth on Balb/c mice bearing 4T1 tumors, fires up the tumor microenvironment by promoting immune detection.
Physicochemical Properties
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M.Wt
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429.69
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Formula
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C28H47NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C1NC2=C(C=C(OCC(C)CCCC(C)CCCC(C)CCCC(C)C)C=C2)CC1
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References
1. Ling Huang, et al. Cell Chem Biol. 2023 May 22;S2451-9456(23)00126-5.
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