NK1-IN-9 |CAS:1100211-97-9 Probechem Biochemicals

Chemical Structure : NK1-IN-9

NK1-IN-9 (NK1/SERT inhibitor)

Catalog No.: PC-60173Not For Human Use, Lab Use Only.

NK1-IN-9 is a potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM).

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Biological Activity

NK1-IN-9 is a potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM).
NK1-IN-9 demonstrates favorable oral bioavailability, excellent brain uptake, and robust in vivo efficacy in a validated depression model.

Physicochemical Properties

M.Wt	436.352
Formula	C22H24Cl2FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3,5-dichloro-7-(1-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)ethyl)-1H-indazole

References

1. Degnan AP, et al. ACS Chem Neurosci. 2016 Dec 21;7(12):1635-1640.

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NK1-IN-9 (NK1/SERT inhibitor)

Biological Activity

Physicochemical Properties

References

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