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Chemical Structure : NK150460
Catalog No.: PC-60775Not For Human Use, Lab Use Only.
NK150460 is a potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.
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NK150460 is a potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.
NK150460 inhibits growth of not only most ER-positive, but also some ER-negative breast cancer cell lines, while never inhibiting growth of non-breast cancer cell lines.
NK150460 inhibits 17β-estradiol (E2)-dependent transcription without affecting binding of E2 to ER.
NK150460 does not induce histone H2AX phosphorylation or p53 expression.
NK150460 is a a novel AhR agonist dependent on AhR/ARNT and cytochrome P450 CYP1A1.
| M.Wt | 308.304 | |
| Formula | C16H15F3N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fukasawa K, et al. Mol Cancer Ther. 2015 Feb;14(2):343-54.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
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