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NK250

Chemical Structure : NK250

CAS No.:

NK250

Catalog No.: PC-26810Not For Human Use, Lab Use Only.

NK250 is a potent, selective, Cullin-Ring-E3 ligase (CRL)-dependent USP7 PROTAC degrader with DC50 of 4 nM in MV4-11 cells (24 h).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NK250 is a potent, selective, Cullin-Ring-E3 ligase (CRL)-dependent USP7 PROTAC degrader with DC50 of 4 nM in MV4-11 cells (24 h).
NK250 (250 nM) induces complete degradation of USP7 with PROTAC NK250 in Panc89 cells.

Physicochemical Properties

M.Wt 1136.43
Formula C62H77N11O8S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-4-hydroxy-1-((S)-2-((1r,4S)-4-(4-(4-(5-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)piperazine-1-carbonyl)cyclohexane-1-carboxamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

References

1. Nikolas Klink, et al. bioRxiv doi: https://doi.org/10.1101/2025.07.01.662351

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