NKP608 | NK1 receptor antagonist | Probechem Biochemicals

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Chemical Structure : NKP608

CAS No.: 177707-12-9

NKP608 (NKP-608)

Catalog No.: PC-45396Not For Human Use, Lab Use Only.

NKP608 (NKP-608) is a non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$298	In stock
25 mg	$488	In stock
50 mg	$788	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NKP608 (NKP-608) is a non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
NKP608 exhibits an anxiolytic-like effect in the social interaction and social exploration test in rats; orally active.

Physicochemical Properties

M.Wt	619.9846
Formula	C31H24ClF6N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-

References

1. Gentsch C, et al. Behav Brain Res. 2002 Jul 18;133(2):363-8.

2. Vassout A, et al. Regul Pept. 2000 Dec 22;96(1-2):7-16.

3. Coulson FR, et al. Inflamm Res. 2002 Jul;51(7):317-23.

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NKP608 (NKP-608)

Biological Activity

Physicochemical Properties

References

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