Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NKTR-181
Catalog No.: PC-60802Not For Human Use, Lab Use Only.
A novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NKTR-181 (Loxicodegol) is a long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold);.
NKTR-181 demonstrates maximum analgesic activity comparable to that of oxycodone in hot-plate latency and acetic-acid writhing models.
NKTR-181 reduces its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists.
| M.Wt | 595.73 | |
| Formula | C31H49NO10 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Miyazaki T, et al. J Pharmacol Exp Ther. 2017 Oct;363(1):104-113.
2. Webster L, et al. Pain Med. 2017 Mar 10. doi: 10.1093/pm/pnw344.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
