NLX-101 (F15599) is a potent, highly selective post-synaptic 5-HT1A receptor agonist with Ki of 3.4 nM.
NLX-101 (F15599) is over 1000-fold selective with respect to the other 5-HT1 receptor subtypes, 5-HT2-7 receptor families, and also numerous GPCRs, transporters, ion channels, and enzymes.
NLX-101 (F15599) activates h5-HT1A receptors with an efficacy superior to that of the prototypical 5-HT1A agonist (+/-)-8-OH-DPAT in cellular model of signal transduction.
NLX-101 (F15599), unlike 5-HT, more potently and efficaciously stimulated G(αi) than G(αo) activation.
NLX-101 (F15599) potently activated ERK1/2 phosphorylation and strongly induced c-fos mRNA expression in rat prefrontal cortex.
NLX-101 (F15599) attenuates muscular hyperalgesia in reserpine-induced myalgia model.
