Chemical Structure : NLX-266
CAS No.:
2170564-20-0
NLX-266
(NLX266)
Catalog No.: PC-24462Not For Human Use, Lab Use Only.
NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors.
NLX-266 preferentially activates ERK1/2 phosphorylation, correlating with significant antidepressant effects in the forced swim test in rats at low doses (MED = 0.63 mg/kg p.o.).
NLX-266 demonstrates potent antiparkinsonian effects by reversing haloperidol-induced catalepsy at very low doses (MED = 0.04 mg/kg p.o.).
Physicochemical Properties
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M.Wt
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427.85
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Formula
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C20H21ClF3N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3-Chloro-4-fluorophenyl)(4-fluoro-4-(((2-((4-fluoropyridin-2-yl)oxy)ethyl)amino)methyl)piperidin-1-yl)methanone
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References
1. Sniecikowska J, et al. J Med Chem. 2025 Apr 23. doi: 10.1021/acs.jmedchem.5c00484.
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