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NLY01

Chemical Structure : NLY01

CAS No.:

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NLY01 (Pegsebrenatide, GLP1R agonist NLY01)

Catalog No.: PC-35834Not For Human Use, Lab Use Only.

Pegsebrenatide (NLY01) is a potent, brain-penetrant long-acting GLP1R agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pegsebrenatide (NLY01) is a potent, brain-penetrant long-acting GLP-1R agonist, protects against the loss of dopaminergic neurons and behavioral deficits in the α-synuclein preformed fibril (α-syn PFF) mouse model of sporadic Parkinson's disease, blocks the microglial activation and the generation of A1 astrocytes.
    Pegsebrenatide (NLY01) also prolongs the life and reduces the behavioral deficits and neuropathological abnormalities in the human A53T α-synuclein (hA53T) transgenic mouse model of α-synucleinopathy-induced neurodegeneration.

    Physicochemical Properties

    M.Wt
    Formula
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    References

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