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NLY01

Chemical Structure : NLY01

CAS No.:

NLY01 (Pegsebrenatide, GLP1R agonist NLY01)

Catalog No.: PC-35834Not For Human Use, Lab Use Only.

Pegsebrenatide (NLY01) is a potent, brain-penetrant long-acting GLP1R agonist.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Pegsebrenatide (NLY01) is a potent, brain-penetrant long-acting GLP1R agonist, protects against the loss of dopaminergic neurons and behavioral deficits in the α-synuclein preformed fibril (α-syn PFF) mouse model of sporadic Parkinson's disease, blocks the microglial activation and the generation of A1 astrocytes.
Pegsebrenatide (NLY01) also prolongs the life and reduces the behavioral deficits and neuropathological abnormalities in the human A53T α-synuclein (hA53T) transgenic mouse model of α-synucleinopathy-induced neurodegeneration.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

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