Chemical Structure : NMD670 sodium
CAS No.:
2354323-05-8
NMD670 sodium
(NMD-670, NMD 670)
Catalog No.: PC-22008Not For Human Use, Lab Use Only.
NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).
NMD670 shows no effect on Gm in a Cl− free experimental solution.
NMD670 (20 mg/kg) enhances neuromuscular transmission and restores muscle function in experimental autoimmune myasthenia gravis (MG) rats.
NMD670 (20 mg/kg) restores muscle force and motor performance in rat models of MG.
NMD670 improves running performance in a passive immunization MG rat model.
Physicochemical Properties
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M.Wt
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335.11
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Formula
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C12H10BrNO4.Na
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-(4-bromo-2-(isoxazol-3-yl)phenoxy)propanoic acid, sodium salt
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References
1. Martin Skov, et al. Sci Transl Med. 2024 Mar 20;16(739):eadk9109.
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