NMS-P118 |CAS:1262417-51-5 Probechem Biochemicals

Chemical Structure : NMS-P118

CAS No.: 1262417-51-5

NMS-P118 (NMS-P 118)

Catalog No.: PC-45571Not For Human Use, Lab Use Only.

NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
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Biological Activity

NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
NMS-P118 exhibits excellent ADME and pharmacokinetic profiles and high efficacy in MDA-MB-436 and Capan-1 xenograft models; orally available.

Physicochemical Properties

M.Wt	395.4187
Formula	C20H24F3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: 16 mg/mL
Chemical Name/SMILES	1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-

References

1. Papeo G, et al. J Med Chem. 2015 Sep 10;58(17):6875-98.

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NMS-P118 (NMS-P 118)

Biological Activity

Physicochemical Properties

References

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