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NMS-P293

Chemical Structure : NMS-P293

CAS No.:

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NMS-P293 (NMS P-293;NMS P293)

Catalog No.: PC-61976Not For Human Use, Lab Use Only.

NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2; NMS-P293 inhibits hydrogen peroxide induced poly ADP-ribose (PAR) synthesis with an IC50 in the single digit nanomolar range; possesses favorable ADME properties, causes complete tumor regressions in mice bearing BRCA mutated breast cancer xenografts.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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