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Chemical Structure : NMT1 inhibitor B13
Catalog No.: PC-61227Not For Human Use, Lab Use Only.
NMT1 inhibitor B13 (LCL4, D-NMAPPD) is a myristoylCoA analog that acts as a small molecule inhibitor of N-myristoyltransferase 1 (NMT1) with IC50 of 77.6 uM, blocks Src myristoylation and Src localization to the cytoplasmic membrane.
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NMT1 inhibitor B13 (LCL4, D-NMAPPD) is a myristoylCoA analog that acts as a small molecule inhibitor of N-myristoyltransferase 1 (NMT1) with IC50 of 77.6 uM, blocks Src myristoylation and Src localization to the cytoplasmic membrane.
NMT1 inhibitor B13 attenuates Src-mediated oncogenic signaling, suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells.
NMT1 inhibitor B13 exerts anti-invasive and antitumor effects against prostate cancer cells, with minimal toxic side-effects in vivo.
| M.Wt | 422.566 | |
| Formula | C23H38N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim S, et al. Cancer Res. 2017 Dec 15;77(24):6950-6962.
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