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Chemical Structure : NN-390
Catalog No.: PC-72740Not For Human Use, Lab Use Only.
NN-390 (NN390) is a potent, selective HDAC6 inhibitor with IC50 of 9.8 nM, >200-550-fold selectivity over other HDAC isoforms.
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NN-390 (NN390) is a potent, selective HDAC6 inhibitor with IC50 of 9.8 nM, >200-550-fold selectivity over other HDAC isoforms.
NN-390 inhibits primary cells of treatment-refractory Group 3 MB cells (SU_MB002) with IC50 of 2.33 uM.
NN-390 is the first HDAC6-selective inhibitor to show therapeutic potential in metastatic Group 3 medulloblastoma (MB), an aggressive pediatric brain tumor often associated with leptomeningeal metastases and therapy resistance.
NN-390 selectively targets cell population with a 44.3-fold therapeutic margin between patient-derived Group 3 MB cells in comparison to healthy neural stem cells.
NN-390 demonstrated a 45-fold increased potency over HDAC6-selective clinical candidate citarinostat.
| M.Wt | 420.379 | |
| Formula | C17H16F4N2O4S | |
| Appearance | Solid | |
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1. Nabanita Nawar, et al. J Med Chem. 2022 Feb 4. doi: 10.1021/acs.jmedchem.1c01585.
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