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NNC-0640

Chemical Structure : NNC-0640

CAS No.: 307986-98-7

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NNC-0640 (NNC 0640, NNC0640)

Catalog No.: PC-70023Not For Human Use, Lab Use Only.

NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM.

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5 mg $98 In stock
10 mg $148 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM.
NNC-0640 also inhibits a penel of mutant GCGRs with IC50 of 100-700 nM.

Physicochemical Properties

M.Wt 573.672
Formula C29H31N7O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((1-(4-cyclohexylphenyl)-3-(3-(methylsulfonyl)phenyl)ureido)methyl)-N-(1H-tetrazol-5-yl)benzamide

References

1. Jazayeri A, et al. Nature. 2016 May 12;533(7602):274-7.

2. Zhang H, et al. Nature. 2017 Jun 8;546(7657):259-264.

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