NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
NNC-711 displays excellent selectivty over rGAT-2, hGAT-3 and hBGT-1, and other other neurotransmitter receptors.
NNC-711 inhibits synaptosomal (IC50=47 nM), neuronal (IC50=1238 nM) and glial (IC50=636 nM) GABA uptake in vitro.
NNC-711 demonstrates potent anticonvulsant activity against rodent seizures induced by DMCM.
