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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-GABA Transporter (GAT)-NNC-711
NNC-711

Chemical Structure : NNC-711

CAS No.: 145645-62-1

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NNC-711 (NNC711)

Catalog No.: PC-62931Not For Human Use, Lab Use Only.

NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
    NNC-711 displays excellent selectivty over rGAT-2, hGAT-3 and hBGT-1, and other other neurotransmitter receptors.
    NNC-711 inhibits synaptosomal (IC50=47 nM), neuronal (IC50=1238 nM) and glial (IC50=636 nM) GABA uptake in vitro.
    NNC-711 demonstrates potent anticonvulsant activity against rodent seizures induced by DMCM.

    Physicochemical Properties

    M.Wt 386.876
    Formula C21H23ClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride

    References

    1. Suzdak PD, et al. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98.

    2. Oh DJ, et al. Epilepsia. 1994 Mar-Apr;35(2):426-30.

    3. Borden LA, et al. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

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