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Chemical Structure : NNC-711
Catalog No.: PC-62931Not For Human Use, Lab Use Only.
NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
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NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
NNC-711 displays excellent selectivty over rGAT-2, hGAT-3 and hBGT-1, and other other neurotransmitter receptors.
NNC-711 inhibits synaptosomal (IC50=47 nM), neuronal (IC50=1238 nM) and glial (IC50=636 nM) GABA uptake in vitro.
NNC-711 demonstrates potent anticonvulsant activity against rodent seizures induced by DMCM.
| M.Wt | 386.876 | |
| Formula | C21H23ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Suzdak PD, et al. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98.
2. Oh DJ, et al. Epilepsia. 1994 Mar-Apr;35(2):426-30.
3. Borden LA, et al. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
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