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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-GABA Transporter (GAT)-NNC 05-2090 hydrochloride
NNC 05-2090 hydrochloride

Chemical Structure : NNC 05-2090 hydrochloride

CAS No.: 184845-18-9

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NNC 05-2090 hydrochloride (NNC05-2090)

Catalog No.: PC-62929Not For Human Use, Lab Use Only.

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
NNC 05-2090 displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively.
NNC 05-2090 inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM.
NNC 05-2090 significantly reduces generalized seizure severity and afterdischarge duration in rats.

Physicochemical Properties

M.Wt 451.01
Formula C27H31ClN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

References

1. Thomsen C, et al. Br J Pharmacol. 1997 Mar;120(6):983-5.

2. Dalby NO, et al. Epilepsy Res. 1997 Jul;28(1):51-61.

3. Jinzenji A, et al. J Pharmacol Sci. 2014;125(2):217-26.

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