Chemical Structure : NNRTI compound 5i3
CAS No.:
2459751-62-1
NNRTI compound 5i3
Catalog No.: PC-24720Not For Human Use, Lab Use Only.
NNRTI compound 5i3 is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), shows potent antiviral activity against NNRTI-resistant strains (GH9, p1579, p5375, p1833, and p5735) with EC50 of 2.6-18.3 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NNRTI compound 5i3 is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), shows potent antiviral activity against NNRTI-resistant strains (GH9, p1579, p5375, p1833, and p5735) with EC50 of 2.6-18.3 nM.
5i3 shows antiviral efficacy comparable to RPV with an EC50 value of 1.16 nM against HIV-1 (NL4-3).
5i3 has antiviral potency of 5i3 against the GH9 strain (EC50 = 11.1 nM), which is about 9.4-fold higher than ETR and 154-fold higher than RPV.
5i3 suppresses the replication of HIV-1 IIIB very effectively at single-digit nanomolar levels (EC50 =1.4 nM).
5i3 as an orally bioavailable NNRTI drug candidate.
Physicochemical Properties
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M.Wt
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568.70
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Formula
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C31H32N6O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(3,5-dimethyl-4-((2-((1-(4-(methylsulfonyl)benzyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
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References
1. Zhao Wang, et al. Sci Adv. 2025 May 30;11(22):eadt8916.
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