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Chemical Structure : NPBA
Catalog No.: PC-21482Not For Human Use, Lab Use Only.
NPBA is a potent, selective pharmacological activator for K2P channel TASK-3 with EC50 of 6.7 uM (TASK-3 whole-cell currents), shows good selectivity between TASK channels.
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NPBA is a potent, selective pharmacological activator for K2P channel TASK-3 with EC50 of 6.7 uM (TASK-3 whole-cell currents), shows good selectivity between TASK channels.
NPBA shows no activity against other K2Ps at 10 uM, including TASK-1, TREK-1, TRESK, and THIK-1.
NPBA mitigated LPS-induced inflammation and lung injury by inhibiting TWIK2 channel.
| M.Wt | 353.30 | |
| Formula | C16H14F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fuyun Tian, et al. Mol Pharmacol. 2019 Jul;96(1):26-35.
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