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NPD976

Chemical Structure : NPD976

CAS No.: 370583-38-3

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NPD976 (NPD-976)

Catalog No.: PC-28535Not For Human Use, Lab Use Only.

NPD976 is a potent insulin secretagogue and voltage-dependent anion channels (VDACs) modulator, is an enhancer of glucose-stimulated insulin secretion (GSIS), selectively enhances insulin secretion under high glucose conditions in INS-1 832/13 cells without affecting the total intracellular insulin content, binds to the VDAC1 and VDAC2 proteins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NPD976 is a potent insulin secretagogue and voltage-dependent anion channels (VDACs) modulator, is an enhancer of glucose-stimulated insulin secretion (GSIS), selectively enhances insulin secretion under high glucose conditions in INS-1 832/13 cells without affecting the total intracellular insulin content, binds to the VDAC1 and VDAC2 proteins.

Physicochemical Properties

M.Wt 443.50
Formula C23H29N3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,4-dimethoxyphenethyl)-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)urea

References

1. Matsunaga K, et al. Cell Chem Biol. 2026 Oct 20:S2451-9456(26)00368-5.

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