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NPY5RA-972

Chemical Structure : NPY5RA-972

CAS No.: 439861-56-0

NPY5RA-972 (NPY5R antagonist)

Catalog No.: PC-38604Not For Human Use, Lab Use Only.

NPY5RA-972 is a potent, highly selective, orally active, and CNS-penetrant neuropeptide Y5 receptor (NPY5) antagonist with IC50 of 3.1 nM, highly selective with respect to Y1, Y2, and Y4 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NPY5RA-972 is a potent, highly selective, orally active, and CNS-penetrant neuropeptide Y5 receptor (NPY5) antagonist with IC50 of 3.1 nM, highly selective with respect to Y1, Y2, and Y4 receptors.
NPY5RA-972 is a highly potent Y5 antagonist in vivo, but chronic administration of NPY5RA-972 (10 mg/kg twice daily) had no effect on food intake or body weight in either free-feeding Wistar rats or dietary obese rats..

Physicochemical Properties

M.Wt 351.44
Formula C21H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide

References

1. Michael H Block, et al. J Med Chem. 2002 Aug 1;45(16):3509-23.

2. Turnbull AV, et al. Diabetes. 2002 Aug;51(8):2441-9.

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