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NQDI-1

Chemical Structure : NQDI-1

CAS No.: 175026-96-7

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NQDI-1 (NQDI1)

Catalog No.: PC-45651Not For Human Use, Lab Use Only.

NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM.
NQDI-1 inhibits in vivo expression levels of ASK1, phosphorylated (p‑)JNK, p‑c‑Jun, p53 and caspase 3 in Hypoxia-ischemia rat model.
NQDI-1 enhances endochondral bone formation by increasing chondrocyte survival in mice.

Physicochemical Properties

M.Wt 319.3108
Formula C19H13NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 10 mg/mL
Chemical Name/SMILES

3H-Naphtho[1,2,3-de]quinoline-1-carboxylic acid, 2,7-dihydro-2,7-dioxo-, ethyl ester

References

1. Volynets GP, et al. J Med Chem. 2011 Apr 28;54(8):2680-6.

2. Hao H, et al. Mol Med Rep. 2016 Jun;13(6):4585-92.

3. Eaton GJ, et al. Cell Death Dis. 2014 Nov 13;5:e1522.

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