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Chemical Structure : NQDI-1
CAS No.: 175026-96-7
Catalog No.: PC-45651Not For Human Use, Lab Use Only.
NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM.
NQDI-1 inhibits in vivo expression levels of ASK1, phosphorylated (p‑)JNK, p‑c‑Jun, p53 and caspase 3 in Hypoxia-ischemia rat model.
NQDI-1 enhances endochondral bone formation by increasing chondrocyte survival in mice.
| M.Wt | 319.3108 | |
| Formula | C19H13NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
3H-Naphtho[1,2,3-de]quinoline-1-carboxylic acid, 2,7-dihydro-2,7-dioxo-, ethyl ester |
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1. Volynets GP, et al. J Med Chem. 2011 Apr 28;54(8):2680-6.
2. Hao H, et al. Mol Med Rep. 2016 Jun;13(6):4585-92.
3. Eaton GJ, et al. Cell Death Dis. 2014 Nov 13;5:e1522.
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