NRG1271 (NRG-1271)

Chemical Structure : NRG1271

Catalog No.: PC-26751Not For Human Use, Lab Use Only.

NRG1271 is an orally bioavailable, brain-penetrant mitochondrial permeability transition pore (mPTP) inhibitor, prevent the mitochondrial gain-of-function toxicity of misfolded TDP-43 and α-synuclein.

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Biological Activity

NRG1271 is an orally bioavailable, brain-penetrant mitochondrial permeability transition pore (mPTP) inhibitor, prevent the mitochondrial gain-of-function toxicity of misfolded TDP-43 and α-synuclein.

Physicochemical Properties

M.Wt	346.31
Formula	C17H13F3N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-Fluoro-3-(7-fluoro-1H-indazol-6-yl)-N-(5-fluoro-2,4-dimethylpyridin-3-yl)acrylamide

References

1. Patent WO2025052129 A1.

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NRG1271 (NRG-1271)

Biological Activity

Physicochemical Properties

References

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