NS-1209 |CAS:245063-59-6 Probechem Biochemicals

Chemical Structure : NS-1209

NS-1209 (NS1209;SPD502)

Catalog No.: PC-61501Not For Human Use, Lab Use Only.

NS-1209 is a selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM.

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Biological Activity

NS-1209 is a selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM.
NS-1209 display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.
NS-1209 inhibits AMPA-induced currents in cortical neurons with IC50 of 0.15 uM.
NS-1209 blocks AMPA-evoked spike activity in rat hippocampus (ED50=6.1mg/kg).

Physicochemical Properties

M.Wt	516.57
Formula	C24H28N4O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,Z)-2-(((5-(4-(N,N-dimethylsulfamoyl)phenyl)-8-methyl-2-oxo-1,2,6,7,8,9-hexahydro-3H-pyrrolo[3,2-h]isoquinolin-3-ylidene)amino)oxy)-4-hydroxybutanoic acid

References

1. Nielsen EO, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1492-501.

2. Erichsen HK, et al. Pain. 2002 Jul;98(1-2):151-61.

3. Langer M, et al. Neuropharmacology. 2011 Oct-Nov;61(5-6):1033-47.

NS-1209 (NS1209;SPD502)

Biological Activity

Physicochemical Properties

References

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