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Chemical Structure : NS-1643
CAS No.: 448895-37-2
Catalog No.: PC-45091Not For Human Use, Lab Use Only.
A small molecule activator of hERG channels that enhances the magnitude of wild-type hERG current in a concentration- and voltage-dependent manner with EC50 of 10.4 uM at -10 mV.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 1 g | Get quote |
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NS-1643 (NS1643) is a small molecule activator of hERG channels that enhances the magnitude of wild-type hERG current in a concentration- and voltage-dependent manner with EC50 of 10.4 uM at -10 mV.
NS-1643 also causes irreversible inhibition of cell proliferation in human mammary gland adenocarcinoma-derived cells.
| M.Wt | 380.2419 | |
| Formula | C15H10F6N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]- |
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1. Hansen RS, et al. Mol Pharmacol. 2006 Jan;69(1):266-77.
2. Casis O, et al. Mol Pharmacol. 2006 Feb;69(2):658-65.
3. Lansu K, et al. Cell Death Dis. 2013 Jun 6;4:e652.
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