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Chemical Structure : NS-2028
CAS No.: 204326-43-2
Catalog No.: PC-61610Not For Human Use, Lab Use Only.
NS-2028 (NS2028) is a potent, specific soluble guanylate cyclase (sGC) inhibitor with IC50 of 30 and 200 nM for basal and NO-stimulated enzymes, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
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| 100 mg | Get quote |
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NS-2028 (NS2028) is a potent, specific soluble guanylate cyclase (sGC) inhibitor with IC50 of 30 and 200 nM for basal and NO-stimulated enzymes, respectively.
NS-2028 inhibits S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates with IC50 of 17 nM, displays 4.7 fold more potent than ODQ (IC50=80 nM).
NS-2028 inhibits NO-dependent relaxant responses in non-vascular smooth muscle.
| M.Wt | 269.1 | |
| Formula | C9H5BrN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-bromo-4H-2,5-dioxa-3,9b-diaza-cyclopenta[a]naphthalen-1-one |
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1. Olesen SP, et al. Br J Pharmacol. 1998 Jan;123(2):299-309.
2. Callsen D, et al. J Immunol. 1998 Nov 1;161(9):4852-8.
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