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Chemical Structure : NS 11021
CAS No.: 956014-19-0
Catalog No.: PC-73206Not For Human Use, Lab Use Only.
NS11021 is a potent and specific activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1).
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
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NS11021 is a potent and specific activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1).
NS11021 activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials at >0.3 uM.
NS11021 increased the open probability of the channel by altering gating kinetics without affecting the single-channel conductance.
NS11021 influenced neither a number of cloned Kv channels nor endogenous Na(+) and Ca(2+) channels (L- and T-type) in guinea pig cardiac myocytes.
NS11021 displayed better specificity and a 10 times higher potency compared with the most broadly applied KCa1.1 opener, NS1619.
NS11021 leads to relaxation of both intracavernous arteries and corpus cavernosum strips primarily through opening of BK(Ca) channels.
| M.Wt | 511.2 | |
| Formula | C16H9BrF6N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea |
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1. Bentzen BH, et al. Mol Pharmacol. 2007 Oct;72(4):1033-44.
2. Kun A, et al. Br J Pharmacol. 2009 Nov;158(6):1465-76.
3. Layne JJ, et al. Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R378-84.
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