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Chemical Structure : NS13001
CAS No.: 1062592-30-6
Catalog No.: PC-60782Not For Human Use, Lab Use Only.
NS13001 is a potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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NS13001 is a potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively.
NS13001 shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects.
NS13001 alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.
| M.Wt | 339.787 | |
| Formula | C16H14ClN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-chlorophenyl)-9-methyl-2-(3-methyl-1H-pyrazol-1-yl)-9H-purin-6-amine |
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1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53.
2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57.
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