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Chemical Structure : NS15370
Catalog No.: PC-60229Not For Human Use, Lab Use Only.
NS15370 is a highly potent positive modulator of Kv7 channels with EC50 of 100 nM (Kv7.2-Kv7.5).
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NS15370 is a highly potent positive modulator of Kv7 channels with EC50 of 100 nM (Kv7.2-Kv7.5).
NS15370 hyperpolarizes and increases spike frequency adaptation of hippocampal CA1 neurons in brain slices.
NS15370 reduces MK-801-induced hyperactivity in models of partial epilepsia.
| M.Wt | 442.442 | |
| Formula | C23H21F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dalby-Brown W, et al. Eur J Pharmacol. 2013 Jun 5;709(1-3):52-63.
2. Jepps TA, et al. Br J Pharmacol. 2014 Oct;171(19):4413-24.
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