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NS3728

Chemical Structure : NS3728

CAS No.: 265646-85-3

NS3728 (Emidurdar, Endovion, SCO-101, SCO101)

Catalog No.: PC-38096Not For Human Use, Lab Use Only.

NS3728 (Emidurdar, SCO-101) is a potent volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.

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Biological Activity

NS3728 (Emidurdar, SCO-101) is a potent volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.
NS3728 blocks red blood cell chloride conductance (IC50 = 0.6 μM).
NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).

Physicochemical Properties

M.Wt 495.18
Formula C16H9BrF6N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea

References

1. Klausen TK, et al. J Cell Physiol. 2007 Mar;210(3):831-42.

2. Schneider L, et al. Pflugers Arch. 2008 Mar;455(6):1055-62.

3. Kjaer K, et al. Brain Res. 2009 Jul 24;1281:15-24.

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