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NS3763

Chemical Structure : NS3763

CAS No.: 70553-45-6

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NS3763 (NS 3763)

Catalog No.: PC-22610Not For Human Use, Lab Use Only.

NS3763 is a noncompetitive antagonist of GLUK5 receptor, inhibits domoate-induced increase in intracellular calcium mediated through the GLU(K5) of kainate receptors with IC50 of 1.6 uM, with no effect on GLU(K6) subtype.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NS3763 is a noncompetitive antagonist of GLUK5 receptor, inhibits domoate-induced increase in intracellular calcium mediated through the GLU(K5) of kainate receptors with IC50 of 1.6 uM, with no effect on GLU(K6) subtype.

Physicochemical Properties

M.Wt 404.38
Formula C22H16N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid

References

1. Christensen JK, et al. J Pharmacol Exp Ther. 2004 Jun;309(3):1003-10.

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