Chemical Structure : NS8593
CAS No.:
875755-39-8
NS8593
(NS-8593)
Catalog No.: PC-28401Not For Human Use, Lab Use Only.
NS8593 is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor, reversibly inhibits recombinant SK3-mediated currents with potencies around 100 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NS8593 is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor, reversibly inhibits recombinant SK3-mediated currents with potencies around 100 nM.
NS8593 also inhibits TRPM7 (melastatin-related TRP cation channel 7).
NS8593 decreased the Ca(2+) sensitivity by shifting the activation curve for Ca(2+) to the right, only slightly affecting the maximal Ca(2+)-activated SK current.
NS8593 inhibited all the SK1-3 subtypes Ca(2+)-dependently (Kd= 0.42, 0.60, and 0.73 uM, respectively, at 0.5 microM Ca(2+)).
NS8593 does not affect the Ca(2+)-activated K(+) channels of intermediate and large conductance (hIK and hBK channels, respectively).
Physicochemical Properties
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M.Wt
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263.34
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Formula
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C17H17N3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-1H-benzo[d]imidazol-2-amine
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References
1. Strøbaek D, et al. Mol Pharmacol. 2006 Nov;70(5):1771-82.
2. Haugaard MM, et al. Heart Rhythm. 2015 Apr;12(4):825-35.
3. Skibsbye L, et al. Cardiovasc Res. 2014 Jul 1;103(1):156-67.
4. Qi XY, et al. Circulation. 2014 Jan 28;129(4):430-40.
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