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Chemical Structure : NS9283
CAS No.: 913830-15-6
Catalog No.: PC-21601Not For Human Use, Lab Use Only.
NS9283 is a potent, positive allosteric modulator of α4β2 nAChR, acts selectively at 3α:2β stoichiometry of α2* and α4* nAChRs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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| 100 mg | Get quote |
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NS9283 is a potent, positive allosteric modulator of α4β2 nAChR, acts selectively at 3α:2β stoichiometry of α2* and α4* nAChRs.
NS9283 selectively increases ACh potency at the 3α:2β receptors while it does not modulate current conducted by the 2α:3β receptors.
NS9283 was demonstrated to increase the potency of ACh-evoked currents in HEK293-hα4β2 cells by left-shifting the concentration–response curve ∼60-fold.
NS9283 has favourable effects on sensory information processing, as shown by reversal of PCP-disrupted pre-pulse inhibition.
NS9283 improved performance in a rat model of episodic memory (social recognition), a rat model of sustained attention.
| M.Wt | 248.25 | |
| Formula | C14H8N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[3-(3-pyridyl)-1,2,4-oxadiazol-5-yl] benzonitrile |
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1. Timmermann DB, et al. Br J Pharmacol. 2012 Sep;167(1):164-82.
2. Grupe M, et al. Br J Pharmacol. 2013 Apr;168(8):2000-10.
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